Basic Information
VIS ID
TVIS30015682
Fusion event
HIV-ILF3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10772549/10661873 (Hg38)
End
10772325/10661873 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ILF3
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-1296-5p ; hsa-mir-532-3p ; hsa-mir-769-5p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-484 ; hsa-mir-200c-3p ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-149-5p ; hsa-mir-17-5p ; hsa-mir-590-5p ; hsa-mir-136-5p ; hsa-mir-204-3p ; hsa-mir-3192-5p ; hsa-mir-4314 ; hsa-mir-4646-5p ; hsa-mir-4729 ; hsa-mir-4778-5p ; hsa-mir-5187-5p ; hsa-mir-619-5p ; hsa-mir-6506-5p ; hsa-mir-6728-5p ; hsa-mir-6819-3p ; hsa-mir-6877-3p ; hsa-mir-7109-3p
Nearest miRNA
hsa-mir-1181/Upstream/109669; hsa-let-7e/Downstream/56531;
Nearest TSS
ENST00000633603/Upstream/6377; ENST00000587941/Downstream/8639;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6742, chr19-CpG: 39/Downstream/39468
Upstream sequence
cgcctcagcctcccaaagtggtgggattacaggtgggagccactgtgcccggccGGTTGCTTTCTAAGAATAATTTTCAATGTGCCCTTGATGGCGTGAC
Downstream sequence
TCTGTCAAAGTTCAAGGAGTCACCAAGACTCCTAGCTCAAGTGTATCATTTCAGCTCACAGCCCAGGATGGGCCAGCTCCAGAGGTCAGGAAACCAGGAG
Target sequence
tcccgaggagctgggattacaggcatgcaccaccacaccgggctaattttgtatttttagtagagatggagtttctccaagttggtcaggccggtctggaactcccaacctcaggtgatccacccgcctcagcctcccaaagtggtgggattacaggtgggagccactgtgcccggccGGTTGCTTTCTAAGAATAATTTTCAATGTGCCCTTGATGGCGTGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate