Basic Information
VIS ID
TVIS30015685
Fusion event
HIV-DNM2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10838392/10727716 (Hg38)
End
10838352/10727716 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
DNM2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-130a-3p ; hsa-mir-615-3p ; hsa-mir-92a-3p ; hsa-mir-6875-5p ; hsa-mir-6809-5p ; hsa-mir-765 ; hsa-mir-711 ; hsa-mir-4784 ; hsa-mir-4708-3p ; hsa-mir-3150b-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4761-3p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125
Nearest miRNA
hsa-mir-1181/Upstream/9213; hsa-let-7e/Downstream/52538;
Nearest TSS
ENST00000633603/Upstream/9155; ENST00000588976/Downstream/27405;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/9052, chr19-CpG: 70/Downstream/108124
Upstream sequence
gcctcggcttcccaaagtgctgggattacaggcaagagccacggcacccggccTAGGTTAGATTTAGAGTTTTCAGAGTTGGCTTAGGCGGTAGAGGCTG
Downstream sequence
GCCTTTGAATGGAACCCTGTCTCGCTGTCGCTCTCAGCGTTTATATTTGGCTCAGAGCCACATCTGCCAAACTTCTGCCCGATTTGAATGAAAGTGCTGA
Target sequence
GATTTAGAGTTTTCAGAGTTGGCTTAGGCGGTAGAGGCTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate