Basic Information
VIS ID
TVIS30015690
Fusion event
HIV-ZNF823 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
11836334/11725519 (Hg38)
End
11836190/11725519 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF823
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-1181/Upstream/229897; hsa-let-7e/Downstream/978082;
Nearest TSS
ENST00000633603/Upstream/85743; ENST00000462251/Downstream/13363;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/30434, chr19-CpG: 42/Downstream/13025
Upstream sequence
TTCCAAGCATTTATTCGATGACATAGTAAACCCACTCTTATTTTGTCTACACTCACTTTTTCCCACAAAGCCATTGTGATGCTTTAGTTGAATGTGTTTG
Downstream sequence
GTAAAGTAACAGTCGAATAGGAACCTGCCTCTTGTTGGTGAGTTAAGTGAGTGAGTCTTATTGCCTGCGTCACCCCTGATGTCTATTTCTACAGCGGTCT
Target sequence
TGAGAATCCATACTCACTGCATAAACTTTGCATGATGCTGTGGTTTCCAAGCATTTATTCGATGACATAGTAAACCCACTCTTATTTTGTCTACACTCACTTTTTCCCACAAAGCCATTGTGATGCTTTAGTTGAATGTGTTTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate