Basic Information
VIS ID
TVIS30015691
Fusion event
HIV-ZNF136 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12278194/12167379 (Hg38)
End
12278164/12167379 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF136
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-8067 ; hsa-mir-4684-5p ; hsa-mir-6508-5p ; hsa-mir-3613-3p ; hsa-mir-3675-3p ; hsa-mir-5680 ; hsa-mir-28-3p ; hsa-mir-6771-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-2278 ; hsa-mir-5692a ; hsa-mir-1276
Nearest miRNA
hsa-mir-1181/Upstream/671757; hsa-let-7e/Downstream/536222;
Nearest TSS
ENST00000633603/Upstream/4263; ENST00000476676/Downstream/17239;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3903, chr19-CpG: 66/Downstream/27358
Upstream sequence
TCTCATTCTAGTACATTGAAGAGTCATGAAGCCAAATCTTTGATGGTCTGTGTCAGAGACACAAATTTAAGGAATGTTTGgttaacaaatgttttgttcc
Downstream sequence
cactgatcagtgaagacaaaactgttcagctaatgttttatgaagcaaagaatgggcatttgTAgacctgatgccatggctcacgcttgtaagcccatca
Target sequence
GGAATGTTTGgttaacaaatgttttgttcc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate