Basic Information
VIS ID
TVIS30015693
Fusion event
HIV-chr19 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
13270571/13159757 (Hg38)
End
13270420/13159757 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-10395/Upstream/219217; hsa-let-7e/Downstream/676530;
Nearest TSS
ENST00000633603/Upstream/5564; ENST00000587098/Downstream/54794;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3541, chr19-CpG: 45/Downstream/3081
Nearby gene
IER2(No orient, 4853)
Upstream sequence
TACCAATGTCCAGCCTGAGCCTGAATGAGTGAATGAGGTTGTTTTGGGTAAACAGGTGTTACATGCTTAATGTTTATCATCTCATTAAATCAGTGGCTTC
Downstream sequence
TACATGACTCTTAGAATTTCTCAAACCTCAGATGGTTGAGGGGTCAGGATATTTGTGATATTTTCATAACTACTGTACTAttattattatcatttataga
Target sequence
ATTTTTTACTTAGGATTTGTGCCCTAACTCAGAAGTTAATTCTGTTAATTCTACCAATGTCCAGCCTGAGCCTGAATGAGTGAATGAGGTTGTTTTGGGTAAACAGGTGTTACATGCTTAATGTTTATCATCTCATTAAATCAGTGGCTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate