Basic Information
VIS ID
TVIS30015694
Fusion event
HIV-chr19 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
13275517/13164703 (Hg38)
End
13275653/13164703 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-10395/Upstream/224163; hsa-let-7e/Downstream/671584;
Nearest TSS
ENST00000633603/Upstream/10510; ENST00000587098/Downstream/49848;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/1401, chr19-CpG: 93/Downstream/42529
Nearby gene
IER2(No orient, 9799)
Upstream sequence
CCCAGAGGGTCTTCCTGGACGAGGGGGAGGGGACAGGCTGAAGAACAATGGGGCTTCTGTGGCTGCAGGACGCCAGGCACTTCCTGTTAACCCTTTCCTC
Downstream sequence
GTGAATCACACCTTTTCTCACTTGATGGAGTTACAGGGCTTTCTCCTCTATTGCTGAGGGCTGTGCAGTCAGGGACGGGGCAGGGCTAGCCTGGGAGAAG
Target sequence
GGGGTGCAGCTGCAGGGAGCACCTCCCAGGTCCCGCCTTGTGGGAAGGGGCAGAGGCAGCCTGAGGGGAAATCTTGTTGCGGGAATTAACTGTTGTGTTAATTGAGGCTTTTGTGAGTGTACTTAGGAGGGGTGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate