Basic Information
VIS ID
TVIS30015699
Fusion event
HIV-RASAL3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
15572384/15461573 (Hg38)
End
15572544/15461573 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA19B
Target gene
RASAL3
miRNAs that regulate target gene
hsa-mir-615-3p
Nearest miRNA
hsa-mir-10395/Upstream/11965; hsa-let-7e/Downstream/2820504;
Nearest TSS
ENST00000633603/Upstream/3456; ENST00000601005/Downstream/2941;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3157, chr19-CpG: 60/Downstream/7998
Upstream sequence
ctcctctcctccAAGCAGCACCAGCTTCCCATCAAGCAGGGTGAAGCCCCCAATGTCCCAGACAGGCACGTTGGGTGTGGGGGCCTCAGGGATCTGTGGG
Downstream sequence
ACTGTATGACCTTGGGCAAGCTTTCATCGCTGTCTGGGCCTTGTCCCCACTAACCATGGGTAGCAGACACAACTcacctaccatgtgcccagtaccctgt
Target sequence
GTAGGGGGCTCCAGCTCTGGCTCCGGCTCCAGCTCTGGGAAGAAGAGGAGGCACTGGGGGACTTAAGAGACGTTTTCTCTCCCTCAGGCTACCCTTTCCATTCCCGAAGGCTCATGGTGGGTTCCCTCCTAGGTGCCCCCCACCCCAGCAGCCGTATCAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate