Basic Information
VIS ID
TVIS30015700
Fusion event
HIV-CYP4F22 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
15644391/15533580 (Hg38)
End
15644199/15533580 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
CYP4F22
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10395/Upstream/83972; hsa-let-7e/Downstream/2748497;
Nearest TSS
ENST00000633603/Upstream/8247; ENST00000590209/Downstream/80973;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/61486, chr19-CpG: 28/Downstream/17722
Upstream sequence
acatcatagaaagagaaccacataaaatgtgatctttttgtgtctgttttcttttactcagcataatgtttttgaagttcattcacgttgtagtaggaat
Downstream sequence
cagtttcattcttttttttttttttttttttttgagacagggtcttaccctgtcacccagaggctggagtgcagtggtgtagccataactcattacagcc
Target sequence
cattgagtaatcacttcccatttccctcctcctcccatccgctggtaacctcgaatctgctttctgtctctatgtatttgcctattctgggtacatcatagaaagagaaccacataaaatgtgatctttttgtgtctgttttcttttactcagcataatgtttttgaagttcattcacgttgtagtaggaat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate