Basic Information
VIS ID
TVIS30015705
Fusion event
HIV-MYO9B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
17199823/17089013 (Hg38)
End
17199883/17089013 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
MYO9B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-484 ; hsa-mir-93-5p ; hsa-let-7e-5p ; hsa-mir-154-5p ; hsa-mir-6794-3p ; hsa-mir-615-5p ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-4639-3p ; hsa-mir-4714-5p ; hsa-mir-193a-5p
Nearest miRNA
hsa-mir-10395/Upstream/1639405; hsa-let-7e/Downstream/1193064;
Nearest TSS
ENST00000633603/Upstream/13227; ENST00000593411/Downstream/10294;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/12590, chr19-CpG: 60/Downstream/12656
Upstream sequence
actcctaggctcaagtagcctcccaaagtgctaggattacaggaataagccaccacgcctggccATATCCCCACTTTCTGAAATGCCCCAAAAGAGCTTA
Downstream sequence
TCTTGAGTGTCCTCTTCCTCCCGACTGGCACGTGAGCGTGGCCATCTTATGGTTAGGTTGCAGGTGTAGAAAAATGAGGACAAAGGTCTCTAAGTCGTCC
Target sequence
GTTCCTCCCTCCTGTCACCTGCAGTGGGCCATCTCTTGGAGTTTTCTTAACAATTTCTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate