Basic Information
VIS ID
TVIS30015708
Fusion event
HIV-IL12RB1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
18179987/18069177 (Hg38)
End
18180090/18069177 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
IL12RB1
Nearest miRNA
hsa-mir-10395/Upstream/2619569; hsa-let-7e/Downstream/212900;
Nearest TSS
ENST00000633603/Upstream/59628; ENST00000601226/Downstream/17753;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/16971, chr19-CpG: 36/Downstream/28434
Upstream sequence
CTGTCTCCTCAGGCTGTGTATTCTTCAAGGAACAGGCTGAGGCTGAGGCTTTCTGGGGCTCTGGCAAGGCCCAGAGCAGGAAGCGGGAGAGTGAGAGGCC
Downstream sequence
CACCTTGGGATGTGAGATTCATTACCTGTATGTGTGTGATCTGCCTGGAACTGAGCTCAGGATGCCAGCAAGAGGTTCCAGACCCATATGGGTGAGAggc
Target sequence
ACCTGAGCCTCACGGCCCCCCTTTCCCTAAAGACTGCTCATTAATTTGCCACCAGCATCTCGCGAACTGCCACCTTCCCTGGCGCGGTTGAATATTTAACAAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate