Basic Information
VIS ID
TVIS30015713
Fusion event
HIV-SUGP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
19400800/19289991 (Hg38)
End
19400683/19289991 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
SUGP1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-92a-3p ; hsa-mir-6728-5p ; hsa-mir-6878-3p ; hsa-mir-5187-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-6744-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-4707-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-212-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-10395/Upstream/903357; hsa-let-7e/Downstream/145072;
Nearest TSS
ENST00000633603/Upstream/8499; ENST00000592069/Downstream/12464;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/16517, chr19-CpG: 18/Downstream/15893
Upstream sequence
gtcgccctatgtgactcttcatctgAAAAAATCCCTCAAGTCAAGAATACAAGGAACTAAGAGGGAGTTAGGAAGAATATAAGGGCCATGTACTCGGCCC
Downstream sequence
CCAACCCCTAATCTCGGTGGGTGTGGGTGATAGGAAATTTATGTCTGGAGATCTAAGAGCAACATGAACTTCTGCTCTGCTTCTCTTCTAGAATTTTAAG
Target sequence
cgccccttcccccatacgtcgccctatgtgactcttcatctgAAAAAATCCCTCAAGTCAAGAATACAAGGAACTAAGAGGGAGTTAGGAAGAATATAAGGGCCATGTACTCGGCCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate