Basic Information
VIS ID
TVIS30015724
Fusion event
HIV-URI1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30461559/29970652 (Hg38)
End
30461688/29970652 (Hg38)
Orient
+
Location type
Intronic
Target gene
URI1
miRNAs that regulate target gene
hsa-mir-598-3p ; hsa-mir-376a-5p
Nearest miRNA
hsa-mir-10395/Upstream/9571298; hsa-let-7e/Downstream/5152048;
Nearest TSS
ENST00000633603/Upstream/28341; ENST00000576442/Downstream/441;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/27694, chr19-CpG: 51/Downstream/251849
Nearest cancer related gene
URI1(OG, No orient, 0)
Upstream sequence
ATTGTTTTAGTATTATAAACATAGTTTAAACTGGCTGTGAAGTGCTTACAGTCTTGATCATAATTCACTGGGGAACAAATGAGCTGTTCAGAGCATCTCC
Downstream sequence
CAGTCATTTTTTTTAACTGACGAAACGTGGATGTTACATTGGTTTCTTGTTATTTATAACATTTATGTATTCTACAAAATATGTAATATTGAAAACAGGT
Target sequence
TTATCCCAAGTATTTCTTCTTGAAAATGTAGTAGAAAAATATCACTGAATTCATTTTTTAATGCGTCAGAATAAAAATTACAGGTGAAAATGTTTGGAGATATACTGACAAAATAAAATATTGTCACTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate