Basic Information
VIS ID
TVIS30015730
Fusion event
HIV-UBA2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
34942292/34451387 (Hg38)
End
34942379/34451387 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
UBA2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-941 ; hsa-mir-330-5p ; hsa-mir-93-3p ; hsa-mir-484 ; hsa-mir-181a-5p ; hsa-mir-34a-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-26a-5p ; hsa-mir-133a-3p ; hsa-mir-5096 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-197-3p ; hsa-mir-4716-5p
Nearest miRNA
hsa-mir-10395/Upstream/14052033; hsa-let-7e/Downstream/671313;
Nearest TSS
ENST00000633603/Upstream/1103; ENST00000588585/Downstream/7327;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/22332, chr19-CpG: 209/Downstream/29762
Upstream sequence
ACCCATTGAAACTTAAAAGATCCCGGGAGACTTGGGATATCATTTTGGAGCAGTTCTCAACAATCAGGGATAGTTATCAAACAGATTTAATTATGACTCT
Downstream sequence
ctcccagtaatcctatgaggtaCTGAGGTGGTCTTGTACCTTTCCTATCTCAGGTTTAACAGtttttttttttttttttttttttttttttgagacagag
Target sequence
AGTAGTGTCCGCTTACTGAGTTCTCATTctcactaggtgctgggcctaatgcttatttatcatcttatctacattatatcttcaaat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate