Basic Information
VIS ID
TVIS30015736
Fusion event
HIV-WDR62 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
36570534/36079632 (Hg38)
End
36570382/36079632 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
WDR62
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-877-3p ; hsa-mir-769-5p ; hsa-mir-542-5p ; hsa-mir-615-3p ; hsa-mir-186-5p ; hsa-mir-149-5p ; hsa-mir-1260b
Nearest miRNA
hsa-mir-10395/Upstream/734005; hsa-let-7e/Downstream/3329991;
Nearest TSS
ENST00000633603/Upstream/8026; ENST00000633214/Downstream/31519;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/24469, chr19-CpG: 187/Downstream/33825
Upstream sequence
AGTGTGGAGCTTTGTCCTGGAAGGACAAAGTTCACAGGATCTTCTCCAGTCCCTTTAGGCCTTACCCCTTGCACTCAACTGCTGTTGGGGTGGATGAAAC
Downstream sequence
CCTCCTACTTTCAGCTGCTGTTCAGTTTGGCCCAGTGTGCTTTCCAATGAACACCTCTTGGCTACTTTGGAATTATCCTGTTGCTGGGTCTGTCAGATGC
Target sequence
TGTCCCTGTTGTGATTGGTCAATTTCATTTCTACTCTTAGCAGTTTCTCTTCAGTGTGGAGCTTTGTCCTGGAAGGACAAAGTTCACAGGATCTTCTCCAGTCCCTTTAGGCCTTACCCCTTGCACTCAACTGCTGTTGGGGTGGATGAAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate