Basic Information
VIS ID
TVIS30015738
Fusion event
HIV-ZNF875 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
37820603/37329701 (Hg38)
End
37820665/37329701 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF875
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-4674 ; hsa-mir-3115 ; hsa-mir-6824-5p ; hsa-mir-193a-5p ; hsa-mir-4437 ; hsa-mir-6783-5p ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-10395/Upstream/1984074; hsa-let-7e/Downstream/2079922;
Nearest TSS
ENST00000633603/Upstream/11662; ENST00000590386/Downstream/4923;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11570, chr19-CpG: 45/Downstream/4498
Nearby gene
ZNF875(No orient, 4976)
Upstream sequence
TGTCCATCATTACGTATCTGTGGTGTCTAGCACATTCCTCTACCTTATTTTCTGTCATTGTACCTACTTCTACCTGAACACGTATTAAATATCTTATTAA
Downstream sequence
AGTGGACTACAGTGTGGTACCTGCAGGTCTCAGGCCTTCTGGGAGGTTCCAGCTTTTCCTGGATGCTCTCTCTCTCTGGCCAGCTCAGGCTGGAGCAGTG
Target sequence
AAATACACAAATATTATGTTTCCTCAGTGGTTTTTTCCCCCTCACATTGGGCCCTCCTCTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate