Basic Information
VIS ID
TVIS30015740
Fusion event
HIV-ZNF540 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
38090178/37599277 (Hg38)
End
38090116/37599277 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF540
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-10395/Upstream/2253650; hsa-let-7e/Downstream/1810346;
Nearest TSS
ENST00000633603/Upstream/4024; ENST00000589285/Downstream/11711;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/4367, chr19-CpG: 119/Downstream/55648
Upstream sequence
cgatagatagatagatagatagataAACTTAAAGGAAAAAGAGGATATAGGATTCTTTTTTATGTATTAAGTGGTTTTTCTTAAAGTATTTATTATTAAG
Downstream sequence
TAATAATTTATTGAGAATTTTTGAGGTAGAAATATAGTTTATTTGCTTGTATCCACTGTTTAATTGAATTGGGAAACATTTATTTGTTCCCAGAAATGTT
Target sequence
AAGAGGATATAGGATTCTTTTTTATGTATTAAGTGGTTTTTCTTAAAGTATTTATTATTAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate