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Viral Integration Site DataBase
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TVIS30015744
Basic Information
VIS ID
TVIS30015744
Fusion event
HIV-SAMD4B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
39851186/39360546 (Hg38)
End
39851412/39360546 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
SAMD4B
miRNAs that regulate target gene
hsa-mir-744-5p
;
hsa-mir-92b-5p
;
hsa-mir-93-3p
;
hsa-mir-320a
;
hsa-mir-30d-5p
;
hsa-mir-93-5p
;
hsa-let-7a-5p
;
hsa-mir-6758-5p
;
hsa-mir-6856-5p
;
hsa-mir-4726-5p
;
hsa-mir-4640-5p
;
hsa-mir-6799-5p
;
hsa-mir-6851-5p
;
hsa-mir-3689d
;
hsa-mir-7854-3p
;
hsa-mir-3918
;
hsa-mir-6865-5p
;
hsa-mir-6815-5p
;
hsa-mir-6895-5p
;
hsa-mir-6859-5p
;
hsa-mir-3916
;
hsa-mir-3125
;
hsa-mir-4700-5p
;
hsa-mir-6857-5p
;
hsa-mir-3915
;
hsa-mir-92a-2-5p
;
hsa-mir-4450
;
hsa-mir-3649
;
hsa-mir-5187-5p
;
hsa-mir-1255b-5p
;
hsa-mir-1255a
;
hsa-mir-4644
;
hsa-mir-4306
;
hsa-mir-185-5p
;
hsa-mir-4533
;
hsa-mir-1827
;
hsa-mir-3928-3p
;
hsa-mir-1252-5p
;
hsa-mir-940
;
hsa-mir-6893-5p
;
hsa-mir-6876-5p
;
hsa-mir-6808-5p
;
hsa-mir-4476
;
hsa-mir-4428
;
hsa-mir-651-3p
;
hsa-mir-762
;
hsa-mir-5001-5p
;
hsa-mir-4498
;
hsa-mir-4430
;
hsa-mir-4492
;
hsa-mir-3652
;
hsa-mir-765
;
hsa-mir-6894-5p
;
hsa-mir-7154-3p
;
hsa-mir-766-5p
;
hsa-mir-6837-5p
;
hsa-mir-3135b
;
hsa-mir-4685-5p
;
hsa-mir-4446-3p
;
hsa-mir-4506
;
hsa-mir-2682-5p
;
hsa-mir-34b-5p
;
hsa-mir-449c-5p
;
hsa-mir-4514
;
hsa-mir-4692
;
hsa-mir-491-5p
;
hsa-mir-622
Nearest miRNA
hsa-mir-10395/Upstream/4014919; hsa-let-7e/Downstream/49077;
Nearest TSS
ENST00000633603/Upstream/3730;
ENST00000596319/Downstream/9007;
Nearest CpG islands
None/Target,
chr19-CpG: 112/Upstream/17513
,
chr19-CpG: 72/Downstream/30146
Upstream sequence
AAAGGAAAACTTAGAATGAGGGAAGGCCATGGTGTGTTCCAGAGTCAGCAGGAAGCCTGCCAGGACTGGAGCAAAGCATGACTTGAAAGAGAAGTGATCA
Downstream sequence
gtgtttctcaaacttgcatcatcatcagaatcactggggttaggtgactgttacaatccagatttctgccccccatagacctactaaatcagaatcctga
Target sequence
CAGAGGTAAATTCTGGTAGAGTCTTGAATGCCTGTTTTCTAGTAGACCTGAGGGCTCTAAGACTAAGAAGCAGGTGCCTCCTGTTTCACTCCTACCCTCAAGTAGAACCCCACCTGCCTTATTTGTAAAGGAAGGTGCTACTTTCTGGGCCTGGAGACCTGCCTCAAAGAAGGAGCTGTTCATACTCTTGTTTCTCCTCTGGTTATTATGGCCTTCCCATTCCCTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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