Basic Information
VIS ID
TVIS30015746
Fusion event
HIV-PAF1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
39878352/39387712 (Hg38)
End
39878293/39387712 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
PAF1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-1296-5p ; hsa-mir-1226-3p ; hsa-mir-615-3p ; hsa-mir-320a
Nearest miRNA
hsa-mir-10395/Upstream/4042085; hsa-let-7e/Downstream/21911;
Nearest TSS
ENST00000633603/Upstream/946; ENST00000600973/Downstream/1486;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/44679, chr19-CpG: 72/Downstream/2980
Upstream sequence
CTTCCCAACTCTACACCAGAGGTGCTGGCATAGCAGTAAACTTTGAGCCATAAGGGAAGAGTTTTGGAGTCACATTTTTGAACATGGGTTTAAGCATTTC
Downstream sequence
ATTTAAAACATTCATGCTAATTTTATATATTACTCCATACTTTGGCAATGTTTACTTTCACATGAAGTCTGTTACTAATACTGGGAAACTTGGCCCTCTG
Target sequence
TTTGAGCCATAAGGGAAGAGTTTTGGAGTCACATTTTTGAACATGGGTTTAAGCATTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate