Basic Information
VIS ID
TVIS30015754
Fusion event
HIV-CEACAM21 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42063816/41557446 (Hg38)
End
42063630/41557446 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CEACAM21
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10395/Upstream/1187539; hsa-let-7e/Downstream/312181;
Nearest TSS
ENST00000633603/Upstream/7926; ENST00000401445/Downstream/7236;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/35105, chr19-CpG: 28/Downstream/7551
Nearby gene
CEACAM21(No orient, 18714)
Upstream sequence
AGAAAATTCAGAGCTTATATCTCCTAATCCAGTTTTACCCCAAGCCTTTGTTCCTGGGTGAGCCAATTTGGAGATTCAGGAGGTATTATATTGTAGTTGG
Downstream sequence
TAAATCAATTGTGATGTGGGGTCCTGTCGGGTTCGATATCACAAGCAGTATCAGCATGTGAGGACCAGAGCTGTGAACTCAACGCTGTCAATCGACAGCT
Target sequence
tccagtaagacaaatctgtgggtcctccagtcacagacccgttactctgtggcGTGTCACTTAGAATCCTTGTGTGTCTCACCCTCAGAAAATTCAGAGCTTATATCTCCTAATCCAGTTTTACCCCAAGCCTTTGTTCCTGGGTGAGCCAATTTGGAGATTCAGGAGGTATTATATTGTAGTTGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate