VISDB - VIS Detail

Basic Information

VIS ID

TVIS30015756

Fusion event

HIV-POU2F2 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr19

Cytoband

q13.2

Reference genome

GRCh37/hg19

Start

42616319/42112167 (Hg38)

End

42616617/42112167 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA19A

Target gene

POU2F2

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-4768-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4307 ; hsa-mir-5011-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6832-3p ; hsa-mir-410-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-6755-5p ; hsa-mir-6841-5p ; hsa-mir-6512-5p ; hsa-mir-6768-3p ; hsa-mir-6888-3p ; hsa-mir-6794-3p ; hsa-mir-3120-5p ; hsa-mir-1304-3p ; hsa-mir-3162-3p ; hsa-mir-4639-3p ; hsa-mir-510-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-504-5p ; hsa-mir-6839-3p ; hsa-mir-659-3p ; hsa-mir-29b-2-5p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-218-5p ; hsa-mir-129-5p ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-3124-3p ; hsa-mir-323b-5p ; hsa-mir-410-5p ; hsa-mir-494-5p ; hsa-mir-6843-3p ; hsa-mir-6848-3p ; hsa-mir-92a-1-5p

Nearest miRNA

hsa-mir-10395/Upstream/242469; hsa-let-7e/Downstream/21278;

Nearest TSS

ENST00000633603/Upstream/16556; ENST00000559786/Downstream/5265;

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/16401, chr19-CpG: 36/Downstream/20958

Upstream sequence

AAAATTCCAGGACAGACAGGCAACAGCAGATCCCAACCCAGGAACCAGTGGGAGCAACTGGCATGCCTGGGCCAGGCTCCTGGACTCCAAGGCCCTGTGG

Downstream sequence

ttcaagcaattctcttgcctcagccacccgagtagctaggattacaggcgcatgccaccacggccggctaatttttgtacttttagtagagacggggttt

Target sequence

ATGAACTGACCACACACCTCCAGGTGGGCAgttttgattggcctggtacccactgccccttcttcaacttattcaagcaacagaacccatctctttcaggggttacactttcccatcctcaagtcacgaggtccaggtagggctgaccttgccttctctggggtcgagggcaagggctcaaatctagccaGGGGACGTGtttttgtttgtttattttattgagacagagtctcactctgttgcccaggctggagt

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.