Basic Information
VIS ID
TVIS30015757
Fusion event
HIV-CIC integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42780680/42276528 (Hg38)
End
42780781/42276528 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CIC
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-5589-3p ; hsa-mir-6815-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p
Nearest miRNA
hsa-mir-10395/Upstream/143015; hsa-let-7e/Downstream/74603;
Nearest TSS
ENST00000633603/Upstream/7304; ENST00000575839/Downstream/3464;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/2930, chr19-CpG: 111/Downstream/3394
Nearby gene
CIC(No orient, 8136)
Nearest cancer related gene
CIC(TSG, No orient, 0)
Upstream sequence
GAAGGAGGCTGGGTGTGGATGTGGGTAGGAGCCGCTGTGGCTTGGGCTTGGGGCAAGAGCCCTTTCAGGAAGGAGCACTGGCCTGGCCCTTCCCTTTTGG
Downstream sequence
CACCCTGACACCAACATTTTTTACATTTGTTGTTATAGGTGGTACAAGCAAAATTTCACAGCAGGGATTTCTGTCCTTAGGTAATGAAGAAACTAAATCA
Target sequence
GGCTCCAGCCCAGGCCAGTCCCGAGGGACAGGGCACAGGGACACGGGTTATGCCTGCCCCTGATGTTCATATACAGAACTGAGGCTGTGAGCTGTGTGTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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