Basic Information
VIS ID
TVIS30015758
Fusion event
HIV-ZNF234 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
44652316/44148163 (Hg38)
End
44652171/44148163 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF234
miRNAs that regulate target gene
hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-196a-3p ; hsa-mir-4252 ; hsa-mir-5186 ; hsa-mir-3128 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-759 ; hsa-mir-5586-3p ; hsa-mir-4797-5p
Nearest miRNA
hsa-mir-10395/Upstream/1796958; hsa-let-7e/Downstream/505523;
Nearest TSS
ENST00000633603/Upstream/6253; ENST00000586203/Downstream/16910;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6247, chr19-CpG: 18/Downstream/64145
Upstream sequence
ttaggtacttagtctgcgccatacactattccaaatgctatatgtagtttctttttcaacgtttgaaagaactctgtcatgtaagaactatcataccaag
Downstream sequence
atgaaactaggtgaacttatccaagatcacacaactttgaagggtacccttgtgtgcactgaggcatgatggctccagaTCATGACACTAAATGCTGCAG
Target sequence
AAATAGATGATGATGGTAATAATAATAGataatagctaatgtttcttaggtacttagtctgcgccatacactattccaaatgctatatgtagtttctttttcaacgtttgaaagaactctgtcatgtaagaactatcataccaag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate