Basic Information
VIS ID
TVIS30015760
Fusion event
HIV-EML2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
46116777/45613519 (Hg38)
End
46117070/45613519 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
EML2
Nearest miRNA
hsa-mir-10395/Upstream/176815; hsa-let-7e/Downstream/25475;
Nearest TSS
ENST00000633603/Upstream/11307; ENST00000591322/Downstream/2633;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11310, chr19-CpG: 27/Downstream/2677
Upstream sequence
ccttgtacagatggggaaaccgaggctcagagaaggggtggggttggaccagagCTGCCTGAATTTTGTCCCCACCCCTGCTTGCTACCCCCGTCCATCC
Downstream sequence
aatgtgaatccgagcctgcccctgctctgcttaaaacccttccatggctccctggtgatcttagaagaaagcctgtggttctaaggctcagcaggcccca
Target sequence
CCATCTCCCCAAGGGACTCACTCGAGGCTGACAGCAGGGGTAGCTAAACAGGTGAACTTTGCCAAAGTCATCAGCTGAAGCCAGCAACTTCCCATCATGAGAGCGGGCCACAGCGTTGATATCAGTGCCGTCCGCCCCCTCAGACCAGATCCCTGTGGGCAAGATGAAGGGAAGTGGTAAGATGTCAGCTGGAGCCAGGGACCGCCAAGAGGAGCAGATTGCCACTCCAGCCACCTTAATTTGTTCCGACCTAGC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate