Basic Information
VIS ID
TVIS30015763
Fusion event
HIV-SYMPK integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
46352612/45849354 (Hg38)
End
46352495/45849354 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
SYMPK
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-940 ; hsa-mir-760 ; hsa-mir-744-5p ; hsa-mir-92b-3p ; hsa-mir-193b-3p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-10395/Upstream/174330; hsa-let-7e/Downstream/169578;
Nearest TSS
ENST00000633603/Upstream/6282; ENST00000594297/Downstream/5851;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/33351, chr19-CpG: 39/Downstream/13590
Upstream sequence
atgcagaaagcattcagtaaaCACCAAAAAGCATTCGGTAAACACCAGCCATTGCTACTTTAAAGCACTTTGTTTTCTGTAATCACTAGTTTTGCTTGCC
Downstream sequence
TCAGTCTGAGGGCTCAAAAAGTAGGGACCCTTTCCTAGCTTGGCAATAACCCCAGCAGGGTCATTTTCATTGAAGAAAAAAATGAAGGGCCTCCAACAAA
Target sequence
ttagaagagtgcctgacatgcagaaagcattcagtaaaCACCAAAAAGCATTCGGTAAACACCAGCCATTGCTACTTTAAAGCACTTTGTTTTCTGTAATCACTAGTTTTGCTTGCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate