Basic Information
VIS ID
TVIS30015769
Fusion event
HIV-ZC3H4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
47603706/47100449 (Hg38)
End
47603648/47100449 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZC3H4
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-331-3p ; hsa-mir-183-5p ; hsa-mir-34a-5p ; hsa-mir-26b-5p ; hsa-mir-320a ; hsa-mir-218-5p ; hsa-mir-5706 ; hsa-mir-4782-5p ; hsa-mir-516b-5p ; hsa-mir-1299 ; hsa-mir-6077 ; hsa-mir-4455 ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-6514-5p ; hsa-mir-4802-5p ; hsa-mir-8076 ; hsa-mir-3163 ; hsa-mir-7-5p ; hsa-mir-663b ; hsa-mir-7155-3p ; hsa-mir-3136-3p ; hsa-mir-6778-3p ; hsa-mir-1827 ; hsa-mir-361-3p ; hsa-mir-4650-5p ; hsa-mir-3065-3p ; hsa-mir-6513-3p ; hsa-mir-3677-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6510-5p ; hsa-mir-4690-5p ; hsa-mir-6165 ; hsa-mir-6871-3p ; hsa-mir-1224-5p ; hsa-mir-3650 ; hsa-mir-3915 ; hsa-mir-4436a ; hsa-mir-4689 ; hsa-mir-4725-5p ; hsa-mir-4751 ; hsa-mir-5000-3p ; hsa-mir-5004-5p ; hsa-mir-504-5p ; hsa-mir-6858-5p ; hsa-mir-7978
Nearest miRNA
hsa-mir-10395/Upstream/391095; hsa-let-7e/Downstream/126493;
Nearest TSS
ENST00000633603/Upstream/5962; ENST00000594526/Downstream/11780;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/51570, chr19-CpG: 20/Downstream/10702
Upstream sequence
GAACAAATGTGCTCTGTCTCCTTTTCTTCAGCATTCTCAGGTGTCATCATAGCCTGCTCTGTGACATCATGCCATTTCCATGGTAACGTGCCTACGCCAC
Downstream sequence
GGCAACCACCCAAGTGAGACACAAAACTGGCAAAGAGAAGTCCAGGCATCAGCATCTGTACCCTGTACCCTACACCCTCACTTCAACATAAGACAGTCTA
Target sequence
GTCATCATAGCCTGCTCTGTGACATCATGCCATTTCCATGGTAACGTGCCTACGCCAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate