Basic Information
VIS ID
TVIS30015770
Fusion event
HIV-SAE1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
47655988/47152731 (Hg38)
End
47656094/47152731 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
SAE1
miRNAs that regulate target gene
hsa-mir-1229-3p ; hsa-mir-615-3p ; hsa-mir-324-3p ; hsa-mir-151a-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-203a-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-4266 ; hsa-mir-4695-5p ; hsa-mir-4779 ; hsa-mir-1273g-5p ; hsa-mir-6816-3p ; hsa-mir-3651 ; hsa-mir-6779-3p ; hsa-mir-7976 ; hsa-mir-651-5p ; hsa-mir-299-5p ; hsa-mir-103b ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p ; hsa-mir-4687-5p
Nearest miRNA
hsa-mir-10395/Upstream/443377; hsa-let-7e/Downstream/74211;
Nearest TSS
ENST00000633603/Upstream/21836; ENST00000601154/Downstream/69837;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/21624, chr19-CpG: 88/Downstream/73329
Upstream sequence
TTTGTTGAATGGCTTTTACTTTTTAGCTAAACACATTTTATTTTGGCTGCAGAACGTGACGGTCTCATAACTTATATTTTCTACACATTGAAACCTGCAA
Downstream sequence
TCAGGGCAGTGATTCACAGTTTGCAAAACTCAAACCCAGCCAATTTCTTTCTTTCTGCAGGTGTGTCTGACTTGCTGCTCCAGGGATGTCATAGTTAAAG
Target sequence
CTTTTCTTTTGTCTTCTAGCCATAGGGCCCAAAGAACCTGTTGTACCAGTTTGAAACATGCTTTGAGCATGCCCAGAGAGACTGTTCATTAAGATTTATTTAGACA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate