Basic Information
VIS ID
TVIS30015781
Fusion event
HIV-TSKS integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50257395/49754138 (Hg38)
End
50257487/49754138 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
TSKS
Nearest miRNA
hsa-mir-10395/Upstream/71943; hsa-let-7e/Downstream/37728;
Nearest TSS
ENST00000633603/Upstream/6760; ENST00000600199/Downstream/9192;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/7501, chr19-CpG: 74/Downstream/12237
Upstream sequence
cacgcctggctaatttttgtatttttagtagagatgggggtttcaccatattggtcaggctggtctcgaactcctgacctcaggtgatctgcctgacttg
Downstream sequence
gctcacacctgtaatctcagcactttgggaggccaaggcaggtggatcacctgaggtcaggagtttgagaccagcccagccaacatggttaaaccccgtc
Target sequence
gcctcccaaagtgctgagattacaggcgtgagccaccgttccctgctacattatgatactttaaatggccagttttcaggccaggcacggtg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate