Basic Information
VIS ID
TVIS30015784
Fusion event
HIV-MED25 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50326643/49823386 (Hg38)
End
50326748/49823386 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
MED25
miRNAs that regulate target gene
hsa-mir-21-3p ; hsa-mir-324-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10395/Upstream/31452; hsa-let-7e/Downstream/8632;
Nearest TSS
ENST00000633603/Upstream/5044; ENST00000599722/Downstream/7457;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/4881, chr19-CpG: 191/Downstream/27147
Upstream sequence
TGCAGTataagcctatcccgttcagtgtaggaggagactacccagtgtgtaaatagcaagaggctggattgctgggtgctgtattgggggctgggtaccg
Downstream sequence
actctcctggtttgcaaatggataatggtcgcgtgtatctccgtgttgttagaagatcacaggagctaagttgcttgctgtgtgtcgcttagggcctggt
Target sequence
caacctcacagcgatgtttggagaattaagttagttgatgatgtttaatacagtgcctggcatgtattaagtgccgtgtaagtgttTCCTAGGATtttgtgcctc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate