Basic Information
VIS ID
TVIS30015785
Fusion event
HIV-MED25 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50327919/49824662 (Hg38)
End
50327604/49824662 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
MED25
miRNAs that regulate target gene
hsa-mir-21-3p ; hsa-mir-324-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10395/Upstream/32728; hsa-let-7e/Downstream/7356;
Nearest TSS
ENST00000633603/Upstream/6320; ENST00000599722/Downstream/6181;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6157, chr19-CpG: 191/Downstream/25871
Upstream sequence
tgaaagagcgagaccctgtctcgggaaaaaaaaaaaaaaaaaagaGGTGGAAGGAAAATAGACCCAGTGTGTTTCCCATAACATTATGACAACTCAGTTG
Downstream sequence
TTCATTCATATGTTCactcattaattcaacaaatgtttgtggaacaaatcgtcctgggcaccaaggagttagtgggcatgagataggcaaggtcctggcc
Target sequence
CTGGGGCTTGGCACCCACGGGGCTTCAGGAGACTGGCTGAATAAATGAATTAGTATGTAATACAAAAACAACAAATaaatagaaaaaattaaccaggcatggtggtgcacacctgtagtcccagctactcaggaggctgaggtaggaggatcaactgagactgggaggcagaggttgcagtgagccgagattgtgccaccgcactccagcctgggtgaaagagcgagaccctgtctcgggaaaaaaaaaaaaaaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate