Basic Information
VIS ID
TVIS30015789
Fusion event
HIV-ZNF83 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.41
Reference genome
GRCh37/hg19
Start
53191846/52688593 (Hg38)
End
53191957/52688593 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF83
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-155-5p ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-329-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-219a-2-3p ; hsa-mir-219b-3p ; hsa-mir-4452 ; hsa-mir-6844 ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-510-3p ; hsa-mir-488-3p ; hsa-mir-1257 ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-4302 ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6845-3p ; hsa-mir-4752 ; hsa-mir-3911 ; hsa-mir-8056 ; hsa-mir-3691-5p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-4320 ; hsa-mir-1825 ; hsa-mir-664a-3p ; hsa-mir-4729 ; hsa-mir-29b-2-5p ; hsa-mir-584-5p ; hsa-mir-3193 ; hsa-mir-1539 ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-8076
Nearest miRNA
hsa-let-7e/Upstream/406700; hsa-mir-10394/Downstream/978086;
Nearest TSS
ENST00000633603/Upstream/27749; ENST00000594546/Downstream/1881;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/50033, chr19-CpG: 59/Downstream/1293
Upstream sequence
CTTCCTTCCCTGATTCTGTACGTATCTCTCATTCTCCCCTTCTCTCTCTAGCTCTTGTTTTATTTTCCCCCGGGGTTCTGCTCCTCATTTTGTACCTCTC
Downstream sequence
TCATCCTCTATCTCTATATGgacagaaatttaaaaataataagtactgcatttattcactccaagaaaagtaaaagctaaggcccacaatgtggcaaggc
Target sequence
TCCTCTCCTGCTGTTTATCCCCTTCTTCACTCTATTCCTTCTCTTCCACCTCTTCTGCTCCATCCTTGTAACTTATCTAACATCTTGCTGCTCTTCTCCCCAATCTTTTGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate