Basic Information
VIS ID
TVIS30015793
Fusion event
HIV-ZNF444 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
56655086/56143717 (Hg38)
End
56655198/56143717 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF444
miRNAs that regulate target gene
hsa-mir-8085 ; hsa-mir-6721-5p ; hsa-mir-6731-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-4802-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-6760-5p ; hsa-mir-4779 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-625-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-765 ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-185-5p ; hsa-mir-4533 ; hsa-mir-4722-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-1253 ; hsa-mir-6886-5p ; hsa-mir-4768-3p ; hsa-mir-5197-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p
Nearest miRNA
hsa-let-7e/Upstream/755475; hsa-mir-10394/Downstream/2190971;
Nearest TSS
ENST00000633603/Upstream/380; ENST00000591564/Downstream/2371;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/2402, chr19-CpG: 37/Downstream/3122
Upstream sequence
gcaacttgggggtagtaacaccaacctcatgggattgatcagcctgtaaagtttatttgagtGCTAGCCAGAATGCTGGGGTTGGAATATGGAGTCTCTC
Downstream sequence
cacgtgggtgcagcatcggagggggtgatctggggaggctctccaagggggtaataattgcatggaggcctcagtcatgagaaggagtcaggtaagcaaa
Target sequence
GCCCACATGAATTGTAGTGaagaaagtcagcacacagatatcgtaacactagatcttgttaaatgctgaaagaaaactaataagggtgacgtcttagcaactgggggaaggg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate