Basic Information
VIS ID
TVIS30015794
Fusion event
HIV-ZNF766 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
58267515/57756147 (Hg38)
End
58267431/57756147 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA19A
Target gene
ZNF766
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-1273g-3p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-6776-5p ; hsa-mir-661 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6742-3p ; hsa-mir-6849-3p ; hsa-mir-1228-3p ; hsa-mir-508-5p ; hsa-mir-542-3p ; hsa-mir-7156-3p ; hsa-mir-6516-3p ; hsa-mir-1206 ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-8084 ; hsa-mir-665 ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-619-3p ; hsa-mir-34b-3p ; hsa-mir-490-3p ; hsa-mir-1305 ; hsa-mir-5701
Nearest miRNA
hsa-let-7e/Upstream/2367905; hsa-mir-10394/Downstream/578541;
Nearest TSS
ENST00000633603/Upstream/2103; ENST00000396150/Downstream/13508;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8896, chr19-CpG: 51/Downstream/13411
Upstream sequence
gctgatgaacttttttaaaaaatcacacaaaaaccctcataatgttttaagaaagtttacaaatttgtgttgggctgcattcaaagctgtcctgagatac
Downstream sequence
atgcggcccacaagctgcgggttggaccagcttgGCCTAGAGAATTTTTCTGATTACTTGACAAGATGGGCTGTCTTTCCTAGGAATCTCATGATTGTCA
Target sequence
aaaaaatcacacaaaaaccctcataatgttttaagaaagtttacaaatttgtgttgggctgcattcaaagctgtcctgagatac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate