Basic Information
VIS ID
TVIS30015804
Fusion event
HIV-PUM2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
20455530/20255769 (Hg38)
End
20455675/20255769 (Hg38)
Orient
+
Location type
Intronic
Target gene
PUM2
miRNAs that regulate target gene
hsa-mir-125a-5p ; hsa-mir-218-5p ; hsa-mir-34a-5p ; hsa-mir-10a-5p ; hsa-mir-615-3p ; hsa-mir-340-5p ; hsa-mir-134-5p ; hsa-mir-6743-5p ; hsa-mir-6721-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-3616-3p ; hsa-mir-211-3p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-583 ; hsa-mir-3674 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-3684 ; hsa-mir-193b-5p ; hsa-mir-31-3p ; hsa-mir-4494 ; hsa-mir-6890-5p ; hsa-mir-3675-5p ; hsa-mir-649
Nearest miRNA
hsa-mir-3125/Upstream/907264; hsa-mir-10b/Downstream/5072871;
Nearest TSS
ENST00000437798/Upstream/30336; ENST00000272233/Downstream/56487;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/29763, chr2-CpG: 119/Downstream/94483
Upstream sequence
ATTAGTTACAAATTGCTATGTGTTTTCTGTCTTATTATACAGTCTTATGTCTTTCTCCAAACCTCCTTCCCTTCTCTGAGTAAACCTGAAAACATCGTTG
Downstream sequence
ATCCTATTTTTGTATACAATTGCTGGGTATTATCTAGTGACTCATGAAAAACGTGTTGATATTCAAAATTCTAAAATAATGCCCTGCTAACAAATTATAA
Target sequence
GGTATAAATAAAAAACAATTCTAACAGTGATTACCTTTACTTCTTAAAGTAATGTGATTAAACTATTTGTTTTGCAGCTTCAGAAAAATGAAGCTATCTACTGACTATGAAAGAGGAAGAAATTAATGTACATTTACTGTTTTGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate