Basic Information
VIS ID
TVIS30015811
Fusion event
HIV-SPAST integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
32318738/32093669 (Hg38)
End
32318794/32093669 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPAST
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-32-3p ; hsa-mir-1250-3p ; hsa-mir-335-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-190a-3p ; hsa-mir-5687 ; hsa-mir-627-3p ; hsa-mir-5011-5p ; hsa-mir-6758-3p ; hsa-mir-153-5p ; hsa-mir-1285-5p ; hsa-mir-665 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-1273e ; hsa-mir-6514-3p ; hsa-mir-6771-5p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-7160-5p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-3192-5p ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-4768-3p ; hsa-mir-5690 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-7851-3p ; hsa-mir-302f ; hsa-mir-490-3p
Nearest miRNA
hsa-mir-1301/Upstream/4097220; hsa-mir-10b/Downstream/438484;
Nearest TSS
ENST00000437798/Upstream/6167; ENST00000645550/Downstream/5194;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/29272, chr2-CpG: 22/Downstream/71939
Upstream sequence
accttctaataaactgtgtaacttattttttatgtttattgtgtactatctgtcttctccctgttggaatataaactctatggaggagggatccttgtct
Downstream sequence
gccaagttaatgaaGTTGTTTATAACCCTTGGCACTATACCTGATACAGTGTAGGGACTTAATAAATGAATGTTAAATGAAGCTATCttaaaaatatata
Target sequence
atatcccaagtgcctacaacagtgtctagcacatgctagttaccgaataaatattt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate