Basic Information
VIS ID
TVIS30015813
Fusion event
HIV-NLRC4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
32450173/32225104 (Hg38)
End
32450006/32225104 (Hg38)
Orient
-
Location type
Intronic
Target gene
NLRC4
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1301/Upstream/4228655; hsa-mir-10b/Downstream/307049;
Nearest TSS
ENST00000437798/Upstream/59222; ENST00000495355/Downstream/39776;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/59225, chr2-CpG: 51/Downstream/52792
Upstream sequence
TGAGGTAGCAACAATATGTAAATGAATTACTTTTTTTTCCCCTTTTCCTTACTCCTAGGAAATGGAAGGTTGCTTTAATTAAATATTCAGTACTTGTTTT
Downstream sequence
CAAAACTGGAGTCAATCTTTGGCAATATTAAGTCGTTTCCTCTTCTGAAAAAGTAAACACCACCTAACTGTTGTTTCTATGGGTATGTTCCTAACTGTAA
Target sequence
TGATTGTGAATATGGTCTATTATATTTTCCTAGAGTATAAGGGAATCTGATAAATAGTGATTCGTAGTGAGGTAGCAACAATATGTAAATGAATTACTTTTTTTTCCCCTTTTCCTTACTCCTAGGAAATGGAAGGTTGCTTTAATTAAATATTCAGTACTTGTTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate