Basic Information
VIS ID
TVIS30015816
Fusion event
HIV-MAP4K3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
39563264/39336123 (Hg38)
End
39563169/39336123 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAP4K3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7c-5p ; hsa-mir-199a-5p
Nearest miRNA
hsa-mir-1301/Upstream/3864637; hsa-mir-10b/Downstream/8041552;
Nearest TSS
ENST00000437798/Upstream/10190; ENST00000366187/Downstream/43686;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/92056, chr2-CpG: 81/Downstream/100633
Upstream sequence
AGAAAAATAAGTGAAAGAAAAAAAATCTAAACTGGGGAGATGGCAGTATCTTTAGAAATATGCTAAGGATTCCTACCAGAGCACATGCTGTACCACTGGG
Downstream sequence
CTAACCCCAGCACATTCAGAGCACCTGCTCTCCTTTGCCAGCTAAATAAATAAAAGACTATGAGAAggcaggacacagtggctcacgtctgtaatcctgg
Target sequence
AATAAGTGAAAGAAAAAAAATCTAAACTGGGGAGATGGCAGTATCTTTAGAAATATGCTAAGGATTCCTACCAGAGCACATGCTGTACCACTGGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate