Basic Information
VIS ID
TVIS30015818
Fusion event
HIV-EML4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
42502067/42274927 (Hg38)
End
42501961/42274927 (Hg38)
Orient
-
Location type
Intronic
Target gene
EML4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-30b-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-652-3p ; hsa-mir-148b-3p ; hsa-mir-651-3p ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-let-7f-2-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-142-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-5683 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-587 ; hsa-mir-377-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-1301/Upstream/6803441; hsa-mir-10b/Downstream/5102748;
Nearest TSS
ENST00000437798/Upstream/104626; ENST00000480320/Downstream/7982;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/105134, chr2-CpG: 61/Downstream/86005
Nearest cancer related gene
EML4(OG, No orient, 0)
Upstream sequence
GCAAGCATTAGGAGGAATGGGTGAAGGACACAGAAGGGAAAGTGCAACATCAAGTATTTCAATTTTTTGCCTAACAATCACTCTTTCCAAAGATAGTAGA
Downstream sequence
GCAGAAACATCTTCCTCTTCTACTGTACTCCCTGATTTCCAGCTGTTGGGATTCAGAGCTCAAGCTAGTACTATTTGGATTAAAAGGAAGCTGTATTGTC
Target sequence
TGAAGGGCAAGCATTAGGAGGAATGGGTGAAGGACACAGAAGGGAAAGTGCAACATCAAGTATTTCAATTTTTTGCCTAACAATCACTCTTTCCAAAGATAGTAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate