Basic Information
VIS ID
TVIS30015820
Fusion event
HIV-THADA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
43811727/43584588 (Hg38)
End
43811622/43584588 (Hg38)
Orient
-
Location type
Intronic
Target gene
THADA
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-106b-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-1301/Upstream/8113102; hsa-mir-10b/Downstream/3793087;
Nearest TSS
ENST00000437798/Upstream/9775; ENST00000460356/Downstream/7828;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/356776, chr2-CpG: 42/Downstream/11201
Upstream sequence
tgctgtggaaaaaggCTACCCTGAGTGAAAGAAGATGTacaggtattatttctcctctctcccagaacctcctcaaaccaacagccatgggattgaaaac
Downstream sequence
gtaaaaagataaattcttaaaggcaaccaatatgcaacaagacaataacaatagtatttcagaagctgcaaagcagatggatgagtgataactgacagca
Target sequence
gctcctgctgtggaaaaaggCTACCCTGAGTGAAAGAAGATGTacaggtattatttctcctctctcccagaacctcctcaaaccaacagccatgggattgaaaac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate