Basic Information
VIS ID
TVIS30015822
Fusion event
HIV-SPTBN1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
54820689/54593552 (Hg38)
End
54820723/54593552 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2D ; FRA2H
Target gene
SPTBN1
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-215-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p ; hsa-mir-93-5p ; hsa-mir-1301-3p ; hsa-mir-615-3p ; hsa-mir-589-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-331-3p ; hsa-mir-195-5p ; hsa-mir-26a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-145-5p
Nearest miRNA
hsa-mir-1301/Upstream/744347; hsa-mir-10b/Downstream/1389415;
Nearest TSS
ENST00000437798/Upstream/35158; ENST00000496323/Downstream/58966;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/34720, chr2-CpG: 30/Downstream/35409
Nearest cancer related gene
SPTBN1(TSG, No orient, 0)
Upstream sequence
GAGCTGCAGCTGCCTCGAGTCCTGGGTTGTGTTGGTAGGTAAGTGATGTCCAGGCTGCCTAGAGGTGGGGTCCTCAGGTGTGATCTTGGATCCCACTTGT
Downstream sequence
GAGAAGTGTTTGAACCTGAGGGCCTTTACATGGAGAAGTGAGGAGACCTATTCTGCATACTCTGAAGGTGGTGCAAGCCATAGTGGGCCACAGAGACAGG
Target sequence
ACCACATTGTACAGCATTGCAAAGAGGGGATGGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate