Basic Information
VIS ID
TVIS30015829
Fusion event
HIV-PPP3R1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p14
Reference genome
GRCh37/hg19
Start
68419981/68192849 (Hg38)
End
68420043/68192849 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PPP3R1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-183-5p ; hsa-mir-34a-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-532-3p ; hsa-mir-5189-3p ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-376a-3p ; hsa-mir-369-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-9-3p ; hsa-mir-4714-3p ; hsa-mir-656-3p ; hsa-mir-6763-3p ; hsa-mir-6758-3p ; hsa-mir-5587-3p ; hsa-mir-4707-5p ; hsa-mir-4704-5p ; hsa-mir-651-3p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-578 ; hsa-mir-340-5p ; hsa-mir-3185 ; hsa-mir-3163 ; hsa-mir-5692a ; hsa-mir-629-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-623 ; hsa-mir-6734-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-1301/Upstream/1834521; hsa-mir-10b/Downstream/910833;
Nearest TSS
ENST00000437798/Upstream/13016; ENST00000608069/Downstream/58299;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/34740, chr2-CpG: 155/Downstream/58914
Upstream sequence
GCTTTACATTTTCTAGTGGCTTTCTAATACAAAAAGTCTAAAGTCCTCGGCAATACTTAGCCTCAAATTTAAATTTCCATCTTATCTCTTTCCCCATTTC
Downstream sequence
TTCCTTATAAACCTCCTGCTGGAATGGCCTTGCCTGAATTCTCCATTTATGAGACACCTATCAATTTTTCTCTGATAAAAGAAAGGGGTTACTAATGATT
Target sequence
CTTTTCTTTGGCTACAATGCTCTTGGCACATCTCTGCTAAAGTATAGATTTTATACCTCCAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate