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TVIS30015833
Basic Information
VIS ID
TVIS30015833
Fusion event
HIV-AAK1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
69820999/69593867 (Hg38)
End
69821156/69593867 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
;
FRA2E
Target gene
AAK1
miRNAs that regulate target gene
hsa-mir-3663-3p
;
hsa-mir-7848-3p
;
hsa-mir-155-5p
;
hsa-mir-20a-5p
;
hsa-mir-106b-5p
;
hsa-mir-622
;
hsa-mir-148a-5p
;
hsa-mir-3942-3p
;
hsa-mir-5100
;
hsa-mir-26a-2-3p
;
hsa-mir-26a-1-3p
;
hsa-mir-6731-3p
;
hsa-mir-892c-5p
;
hsa-mir-1276
;
hsa-mir-6839-3p
;
hsa-mir-3679-3p
;
hsa-mir-6826-3p
;
hsa-mir-629-5p
;
hsa-mir-4261
;
hsa-mir-875-3p
;
hsa-mir-29a-5p
;
hsa-mir-3920
;
hsa-mir-4308
;
hsa-mir-331-3p
;
hsa-mir-6810-3p
;
hsa-mir-6801-3p
;
hsa-mir-587
;
hsa-mir-145-3p
;
hsa-mir-4698
;
hsa-mir-8063
;
hsa-mir-4272
;
hsa-mir-580-5p
;
hsa-mir-3662
;
hsa-mir-377-3p
;
hsa-mir-216b-3p
;
hsa-mir-362-3p
;
hsa-mir-329-3p
;
hsa-mir-8485
;
hsa-mir-3671
;
hsa-mir-372-5p
;
hsa-mir-888-5p
;
hsa-mir-8070
;
hsa-mir-6759-3p
;
hsa-mir-18a-3p
;
hsa-mir-324-3p
;
hsa-mir-1913
;
hsa-mir-3653-5p
;
hsa-mir-371a-5p
;
hsa-mir-4314
;
hsa-mir-675-5p
;
hsa-mir-4466
;
hsa-mir-6508-3p
;
hsa-mir-4726-5p
;
hsa-mir-4640-5p
;
hsa-mir-24-3p
;
hsa-mir-4284
;
hsa-mir-4746-3p
;
hsa-mir-378g
;
hsa-mir-4486
;
hsa-mir-6860
;
hsa-mir-612
;
hsa-mir-5189-5p
;
hsa-mir-3187-5p
;
hsa-mir-1285-3p
;
hsa-mir-764
;
hsa-mir-500a-5p
;
hsa-mir-2355-5p
;
hsa-mir-6793-3p
;
hsa-mir-889-5p
;
hsa-mir-6131
;
hsa-mir-3663-5p
;
hsa-mir-616-5p
;
hsa-mir-373-5p
;
hsa-mir-371b-5p
;
hsa-mir-6513-3p
;
hsa-mir-6878-3p
;
hsa-mir-378a-5p
;
hsa-mir-6744-3p
;
hsa-mir-4757-5p
;
hsa-mir-6778-3p
;
hsa-mir-212-5p
;
hsa-mir-1224-3p
;
hsa-mir-6813-3p
;
hsa-mir-519d-3p
;
hsa-mir-20b-5p
;
hsa-mir-93-5p
;
hsa-mir-17-5p
;
hsa-mir-3065-5p
;
hsa-mir-3529-3p
;
hsa-mir-3978
;
hsa-mir-497-3p
;
hsa-mir-548aa
;
hsa-mir-548ap-3p
;
hsa-mir-548t-3p
;
hsa-mir-6776-3p
Nearest miRNA
hsa-mir-1301/Upstream/490112; hsa-mir-10b/Downstream/659051;
Nearest TSS
ENST00000437798/Upstream/49358;
ENST00000418066/Downstream/49787;
Nearest CpG islands
None/Target,
chr2-CpG: 135/Upstream/156183
,
chr2-CpG: 136/Downstream/48987
Upstream sequence
tggagaaatcatcacaaacatttattacctgtttctcactcaatgctgggatgcctcagaggctactagagtgtacaatgctacttccctcactcattag
Downstream sequence
ACTCATTAATAAAAACAAGAAAGAATAAAAAGACTGAGGGAGGGGACAGGGTCTCTCCTAAGGTACAAGTTGGAATCCGCTTTTGTGAGCAATTTCTACT
Target sequence
gtagctccagactgtaatccttttaactcctctgccagctttaacatttctgtctttgaccttagcggctcttgccattgttctctactgtcaggttggcgtccttctccattttaatgtattgcttttaatTCAACAGTAAATCAAAAGTATAAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT3
Sample type
PBMC
Age
52
Gender
Male
CpG Island Information
×
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