Basic Information
VIS ID
TVIS30015835
Fusion event
HIV-ANXA4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
69985516/69758384 (Hg38)
End
69985629/69758384 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
ANXA4
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-3134 ; hsa-mir-1246 ; hsa-mir-4320
Nearest miRNA
hsa-mir-1301/Upstream/654629; hsa-mir-10b/Downstream/494534;
Nearest TSS
ENST00000437798/Upstream/16251; ENST00000484219/Downstream/22778;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/15924, chr2-CpG: 105/Downstream/71083
Upstream sequence
ctacaggcgtgagctaccgtacctgaccCCTACTACTAAGGTTAAAAGGAgaccaagcacagaggcttacgcctataagcccagcactttgggaggctga
Downstream sequence
tgtagtcccagctactcaacaggctgagatgggaggattgtttgagcccagaagttccaggctgcagtgagctatgactgtgctactgcactccagcttg
Target sequence
ggcaggaagattggttgaggccagaagcttgagaccagcctgctgggcaacatagggagactctacctctgcaaaaaaattttgaaaattagccggaagtggtggcacatgcc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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