Basic Information
VIS ID
TVIS30015851
Fusion event
HIV-TIA1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
70455967/70228835 (Hg38)
End
70456107/70228835 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
TIA1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-33a-5p ; hsa-mir-26b-5p ; hsa-mir-1229-3p ; hsa-mir-331-3p ; hsa-mir-19a-5p
Nearest miRNA
hsa-mir-1301/Upstream/1125080; hsa-mir-10b/Downstream/24083;
Nearest TSS
ENST00000437798/Upstream/996; ENST00000422380/Downstream/483;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/37657, chr2-CpG: 59/Downstream/19460
Upstream sequence
AGCAACTCAAGCATTTGGAAGATCTGGGTATGAAGCCCAAATGGTGACCTCAAGAAAGGAGGGTATTTTGCCCCTTAGTTGGTGAAAGTAGTTCTAAGGC
Downstream sequence
CAAATATCAAACAAAAAAACTTCAGGTGGTTAGTGAATACCCTTTCAAGAGATTTCATTTTATGTTTAAGAAGATACAATTACCTTGTGAACGCTGTGTG
Target sequence
ATCAGCTGCTACCAAACGGGTCAGAAAGCTTGAACTAGCACCAAAGTAGCGGACAAGTTATACTTGGTCAACACTGAGAAGGGAGAAAAGTATTGCTAGAGAGACAAATAGAAATAATATCTCCTCCCGCCCCCCTCCCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate