Basic Information
VIS ID
TVIS30015854
Fusion event
HIV-ST3GAL5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
86098493/85871370 (Hg38)
End
86098549/85871370 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
ST3GAL5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-186-5p ; hsa-mir-7-5p ; hsa-mir-374a-5p ; hsa-mir-4789-5p ; hsa-mir-6806-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-6499-3p ; hsa-mir-298 ; hsa-mir-4468
Nearest miRNA
hsa-mir-1285-2/Upstream/87693; hsa-mir-10b/Downstream/321656;
Nearest TSS
ENST00000437798/Upstream/1117; ENST00000455121/Downstream/16210;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/98864, chr2-CpG: 104/Downstream/17097
Nearby gene
ST3GAL5(No orient, 3700)
Upstream sequence
ttgggaatatttcaaatcttctcttctagttactttgaattacacaacaaattactgtttactataggcaccctactatgctatcaaacactagaactta
Downstream sequence
GGGCTTTCAGTCAATTTGTAAGACATTTAACTTCTTCAAAATTAAGAATTAACCATTTAATGTAAGAGTAGAATAAATGCCATAAAGCAGTACATGATGA
Target sequence
tttctgtattttcaataattcttAAGGCCCTAATGAAGAAATATAAGGGCAAATTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate