Basic Information
VIS ID
TVIS30015855
Fusion event
HIV-IMMT integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
86408869/86181746 (Hg38)
End
86408978/86181746 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
IMMT
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/398069; hsa-mir-10b/Downstream/11280;
Nearest TSS
ENST00000437798/Upstream/7984; ENST00000610262/Downstream/13256;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/75219, chr2-CpG: 81/Downstream/13199
Upstream sequence
TTAATTATTTCTTGAATACAATTGGTATTTGCTATATGTTTTCTTAATTGGCAAAAAAAAAAATCTATTTTTACTTTAAAAGCTTAGTTTAGACATCTGA
Downstream sequence
GCTAACTATGCAGCTGGTCAACTCCTAGAGGCATTCATTTAAAAGCTGATTTTTGGTTTATCTTAGCATATTGTTAGTCTAAAAGCCAACCATTTTAAGA
Target sequence
AAAATCACCCACAAAGTCTAGCTAAAAACATGGCGTTACAGGATACACACTCAAGGGACAGATCTAACCTCAGCTAACTGATCCAGAAAACCAGGTTTCTCATCTCTAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate