Basic Information
VIS ID
TVIS30015859
Fusion event
HIV-UXS1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
106799061/106182605 (Hg38)
End
106798902/106182605 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
UXS1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-93-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/3750239; hsa-mir-10b/Downstream/2958885;
Nearest TSS
ENST00000437798/Upstream/3063; ENST00000643224/Downstream/11694;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/116658, chr2-CpG: 138/Downstream/10881
Upstream sequence
TAAAAAATTTTAATAATGGTTTTAAGCTAGCCTTTTCATTTTGTGTTCAAAAAGGGCAGAGAGGGAAAGAAGGTGAGAGAGGGATCTAGGAGGACCATCT
Downstream sequence
CCAAACCACAGCACCCACGGGCATGATCCTCAGCCACCACAGCTGTGCCCCAACCCAGAGGGCTGTCAGTGCTCTGGGCTCATtctccatgcctcagttt
Target sequence
CACATTGAGCACCTTGTTTTCTCATTTCTCCTGTATTTTGTAATTTTCAAATGGGAGCTTAAAAAATTTTAATAATGGTTTTAAGCTAGCCTTTTCATTTTGTGTTCAAAAAGGGCAGAGAGGGAAAGAAGGTGAGAGAGGGATCTAGGAGGACCATCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate