Basic Information
VIS ID
TVIS30015863
Fusion event
HIV-IWS1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
128253766/127496190 (Hg38)
End
128253697/127496190 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
IWS1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-193b-3p ; hsa-mir-218-5p ; hsa-mir-599 ; hsa-mir-6844 ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-5192 ; hsa-mir-4533 ; hsa-mir-5584-3p ; hsa-mir-4476 ; hsa-mir-6876-5p ; hsa-mir-4428 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/72572; hsa-mir-10b/Downstream/3994970;
Nearest TSS
ENST00000437798/Upstream/2814; ENST00000563538/Downstream/8601;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/67396, chr2-CpG: 75/Downstream/29812
Upstream sequence
GCCACTCATGCTCTTTTTTCGCTGCAACATCATCTCAAAATCTGACAGAAAGTCCATACTAAAGCAGTAAACAAAAGCAAGTGAAATACAAGTTGTCTTT
Downstream sequence
TAAATACACATTTACTTTCACAACAATTAAGAACACCAAATTTCTTAATTCTAACTCAATGAAGTGCTACCTTCTTTTAAAAGTGCAAATAcagtcatgc
Target sequence
ATCTCAAAATCTGACAGAAAGTCCATACTAAAGCAGTAAACAAAAGCAAGTGAAATACAAGTTGTCTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate