Basic Information
VIS ID
TVIS30015874
Fusion event
HIV-PKP4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
159370503/158513991 (Hg38)
End
159370618/158513991 (Hg38)
Orient
+
Location type
Intronic
Target gene
PKP4
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-218-5p ; hsa-mir-449a
Nearest miRNA
hsa-mir-128-1/Upstream/7145580; hsa-mir-10b/Downstream/672844;
Nearest TSS
ENST00000437798/Upstream/55798; ENST00000629219/Downstream/19194;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/55690, chr2-CpG: 146/Downstream/454351
Upstream sequence
CGCTGTGGTGTTTTATGCCTCTCTGTCTTTGTAGTAAGTCTCATCTTCCCTGACGACCCCGCTCTCCCATGCGAAGTTGAGCTCCCCTCACTTCTGTGGT
Downstream sequence
ATAAATGTGTTTTCATTGAAAACACAGATATGTTGTCATATCTTCCCTCAGTTTGTTTCATGCTCCcattgaacaaacacttttgaatacctactgtgtt
Target sequence
GGTAGATTTTATGCTTGTTTACTCTTGCATTTATCACACTATTTTTACTCCTTTGTTCCTGCTAGACAGCTCTTTCAGCATCATAATGGCCACAAAACCTAACACCATCTGGTGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate