Basic Information
VIS ID
TVIS30015892
Fusion event
HIV-chr2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
204531103/203666380 (Hg38)
End
204531202/203666380 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2I
Nearest miRNA
hsa-mir-10b/Upstream/14533269; hsa-mir-1244-1/Downstream/3116854;
Nearest TSS
ENST00000437798/Upstream/130970; ENST00000458610/Downstream/40095;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/130934, chr2-CpG: 83/Downstream/878836
Nearby gene
CD28(No orient, 40094)
Upstream sequence
atatatatatatatatatatTTAGAACTGGATCTTCCTAGGTTTATTGGTATTCTAGCTCTTTGGAGTGGAGAGATGTTGGCAGCACTTTCTGGAAGATC
Downstream sequence
TCTGGGAAGTGGATCAACTGTCTATGTCCAGTTTATGGCCCCTTCTTCACTATGGGATGGTGTGCTATATTCTGGAGTAAGTTCAAGAGTGGTTCTTGTC
Target sequence
AGTTGTTCTTCTATGTCAGCCTGGTACTCTTAGTCCAAGCAGCCTCTTCAGTTTAAAGGAGAAAAGGAAAATACCATGAAACAAAATCATACTTCCCTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate