Basic Information
VIS ID
TVIS30015895
Fusion event
HIV-CREB1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
End
208441442/207576810 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-34b-5p ; hsa-mir-103a-3p ; hsa-mir-182-5p ; hsa-mir-203a-3p ; hsa-mir-200b-3p ; hsa-mir-34b-3p ; hsa-mir-122-5p ; hsa-mir-181b-5p ; hsa-mir-9-5p ; hsa-mir-27b-3p ; hsa-mir-33b-5p ; hsa-mir-6834-5p ; hsa-mir-433-3p ; hsa-mir-513a-3p ; hsa-mir-513c-3p ; hsa-mir-3606-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-19b-3p ; hsa-mir-578 ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-526b-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-466 ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-376a-5p ; hsa-mir-567 ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-1183 ; hsa-mir-5089-5p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5589-5p ; hsa-mir-5095 ; hsa-mir-4731-5p ; hsa-mir-4252 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-519d-5p ; hsa-mir-1273g-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6504-3p ; hsa-mir-4438 ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-6868-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-4735-5p ; hsa-mir-205-5p ; hsa-mir-664a-3p ; hsa-mir-3145-5p ; hsa-mir-4760-3p ; hsa-mir-548e-5p ; hsa-mir-6835-3p ; hsa-mir-204-5p ; hsa-mir-582-5p ; hsa-mir-150-5p ; hsa-mir-1224-5p ; hsa-mir-1224-3p ; hsa-mir-10b-5p ; hsa-mir-363-3p
Nearest miRNA
hsa-mir-10b/Upstream/307386; hsa-mir-1244-1/Downstream/177997;
Nearest cancer related gene
CREB1(OG, No orient, 0)
Upstream sequence
TAAATCTTTTCCACTCAAACCATACattttaattgatattaataattaatatgaataattttataaaGACCTTCAAATTTTTTTAAGTAACATTAGGTTC
Downstream sequence
CTTATTAGGAGAGCATATTATTACGCTGTTTTTAGAAGCAGTTTGACAAATAGTGATTGTGTTTGTTTTTACAAATGGTGAATCAGTTAGAAAAATAAAA
Target sequence
TTCCACTCAAACCATACattttaattgatattaataattaatatgaataattttataaaGACCTTCAAATTTTTTTAAGTAACATTAGGTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate